domingo, 24 de junio de 2012

Gender Modulates the APOE {varepsilon}4 Effect in... [J Neurosci. 2012] - PubMed - NCBI

Gender Modulates the APOE {varepsilon}4 Effect in... [J Neurosci. 2012] - PubMed - NCBI

J Neurosci. 2012 Jun 13;32(24):8254-8262.

Gender Modulates the APOE {varepsilon}4 Effect in Healthy Older Adults: Convergent Evidence from Functional Brain Connectivity and Spinal Fluid Tau Levels.

Source

Functional Imaging in Neuropsychiatric Disorders Laboratory, Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305, Memory and Aging Center, Department of Neurology, University of California, San Francisco, California 94143-1207, Neuroscience and Behavioral Disorders Program, Duke-National University of Singapore Graduate Medical School, Singapore 169857, and Semel Institute for Neuroscience and Human Behavior, Departments of Psychiatry and Neurology, David Geffen School of Medicine, University of California, Los Angeles, California 90095.

Abstract

We examined whether the effect of the apolipoprotein E (APOE) genotype on functional brain connectivity is modulated by gender in healthy older human adults. Our results confirm significantly decreased connectivity in the default mode network in healthy older APOE ε4 carriers compared with ε3 homozygotes. More important, further testing revealed a significant interaction between APOE genotype and gender in the precuneus, a major default mode hub. Female ε4 carriers showed significantly reduced default mode connectivity compared with either female ε3 homozygotes or male ε4 carriers, whereas male ε4 carriers differed minimally from male ε3 homozygotes. An additional analysis in an independent sample of healthy elderly using an independent marker of Alzheimer's disease, i.e., spinal fluid levels of tau, provided corresponding evidence for this gender-by-APOE interaction. Together, these results converge with previous work showing a higher prevalence of the ε4 allele among women with Alzheimer's disease and, critically, demonstrate that this interaction between APOE genotype and gender is detectable in the preclinical period.
PMID:
22699906
[PubMed - as supplied by publisher]

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