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Dobrava-Belgrade Virus, Germany | CDC EID





EID Journal Home > Volume 15, Number 12–December 2009

Volume 15, Number 12–December 2009
Dispatch
Dobrava-Belgrade Virus Spillover Infections, Germany
Mathias Schlegel,1 Boris Klempa,1 Brita Auste, Margrit Bemmann, Jonas Schmidt-Chanasit, Thomas Büchner, Martin H. Groschup, Markus Meier, Anne Balkema-Buschmann, Hinrich Zoller, Detlev H. Krüger, and Rainer G. Ulrich
Author affiliations: Friedrich-Loeffler-Institut–Institute for Novel and Emerging Infectious Diseases, Greifswald-Insel Riems, Germany (M. Schlegel, T. Büchner, M.H. Groschup, A. Balkema-Buschmann, R.G. Ulrich); Charité-Universitätsmedizin Berlin, Berlin, Germany (B. Klempa, B. Auste, D.H. Krüger); Institute of Slovak Academy of Science, Bratislava, Slovakia (B. Klempa); Landesforstanstalt Mecklenburg-Vorpommern, Schwerin, Germany (M. Bemmann); Bernhard-Nocht-Institute for Tropical Medicine, Hamburg, Germany (J. Schmidt-Chanasit); University of Lübeck, Lübeck, Germany (M. Meier); and University of Rostock, Rostock, Germany (H. Zoller)


Suggested citation for this article

Abstract
We present the molecular identification of Apodemus agrarius (striped field mouse) as reservoir host of the Dobrava-Belgrade virus (DOBV) lineage DOBV-Aa in 3 federal states of Germany. Phylogenetic analyses provided evidence for multiple spillover of DOBV-Aa to A. flavicollis, a crucial prerequisite for host switch and genetic reassortment.

European hantaviruses are emerging viruses that can cause hemorrhagic fever with renal syndrome (HFRS) of differing severities. Dobrava-Belgrade virus (DOBV) is a hantavirus that appears in 3 distinct lineages hosted by different Apodemus species. The DOBV-Af lineage associated with the yellow-necked mouse (A. flavicollis) has caused serious HFRS in southeast Europe with a case-fatality rate <12% (1,2). Human infections with Caucasian wood mouse (A. ponticus)–associated DOBV-Ap have resulted in more moderate than severe HFRS in the southern part of European Russia (3). Mild-to-moderate human DOBV disease in central and eastern Europe has been connected with infection by DOBV-Aa lineage carried by the striped field mouse (A. agrarius) (3–5). Other A. agarius–associated strains, found in Estonia and called Saaremaa virus, have been proposed to form a distinct hantavirus species (6). In Germany, human DOBV cases with mild to moderate clinical outcomes have been detected by serologic investigations (4,7) but only 1 short DOBV-Aa small (S) segment sequence derived from a patient in northern Germany has been identified (8). The natural host and the geographic distribution of DOBV in its reservoir host has remained unknown in Germany.

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