Volume 17, Number 8–August 2011
Research
Human Polyomavirus Related to African Green Monkey Lymphotropic Polyomavirus
Virginie Sauvage, Vincent Foulongne, Justine Cheval, Meriadeg Ar Gouilh, Kevin Pariente, Olivier Dereure, Jean Claude Manuguerra, Jennifer Richardson, Marc Lecuit, Ana Burguière, Valérie Caro, and Marc Eloit Comments to Author
Author affiliations: Institut Pasteur, Paris, France (V. Sauvage, M. Ar Gouilh, K. Pariente, J.C. Manuguerra, M. Lecuit, A. Burguière, V. Caro, M. Eloit); Institut National de la Santé et de la Recherche Médicale, Montpellier, France (V. Foulongne, O. Dereure); University of Montpellier, Montpellier (V. Foulongne, O. Dereure); Pathoquest, Paris (J. Cheval, M. Eloit); Ecole Nationale Vétérinaire d'Alfort, Maisons Alfort, France (J. Richardson, M. Eloit); and Paris Descartes University, Paris (M. Lecuit)
Suggested citation for this article
Abstract
While studying the virome of the skin surface of a patient with a Merkel cell carcinoma (MCC) by using unbiased, high-throughput sequencing, we identified a human polyomavirus nearly identical to human polyomavirus 9, a virus recently reported in blood and urine of renal transplantion patients and closely related to the African green monkey lymphotropic polyomavirus. Specific PCR analysis further identified this virus in 2/8 patients with MCC but in only 1/111 controls without MCC. This virus was shed for >20 months by the MCC index patient and was on the skin of the spouse of the index patient. These results provide information on the viral ecology of human skin and raise new questions regarding the pathology of virus-associated skin disorders.
Polyomaviridae is a family of nonenveloped viruses with a circular double-stranded DNA genome. Natural hosts for Polyomaviridae are primates, including humans and monkeys, cattle, rabbits, rodents, and birds (1). Currently, viruses in this family that infect humans are the opportunistic JC polyomavirus (JCPyV) associated with progressive multifocal leukoencephalopathy in immunocompromised person; BK polyomavirus (BKPyV) associated with interstitial nephritis and hemorrhagic cystitis; KI polyomavirus (KIPyV) identified in respiratory secretions of patients with respiratory symptoms at the Karolinska Institute (Stockholm, Sweden); WU polyomavirus (WUPyV), isolated from patients with similar symptoms at Washington University (St. Louis, MO, USA); Merkel cell polyomavirus (MCPyV), associated with the rare but aggressive Merkel cell carcinoma (MCC); and trichodysplasia spinulosa–associated polyomavirus (TSPyV), associated with a rare skin condition in immunocompromised persons (2).
Two recently identified polyomaviruses, human polyomaviruses 6 and 7 (HPyV6 and HPyV7) have been detected in cutaneous swab specimens of healthy persons (3). HPyV9 has been identified by consensus PCR in blood and urine of asymptomatic renal transplant recipients (4). In this study of the skin virome of a patient with MCC, using high-throughput sequencing (HTS) and comparing sequences from a patient with MCC with sequences from healthy controls, we identified a human polyomavirus strain nearly identical to HPyV9, a virus species closely related to the lymphotropic polyomavirus (LPV).
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Suggested Citation for this Article
Sauvage V, Foulongne V, Cheval J, Ar Gouilh M, Pariente K, Dereure O, et al. Human polyomavirus related to African green monkey lymphotropic polyomavirus. Emerg Infect Dis [serial on the Internet]. 2011 Aug [date cited]. http://www.cdc.gov/EID/content/17/8/110278.htm
DOI: 10.3201/eid1708.110278
Comments to the Authors
Please use the form below to submit correspondence to the authors or contact them at the following address:
Marc Eloit, Department of Virology, Institut Pasteur, 28 Rue du Docteur Roux, F-75015 Paris, France; email: marc.eliot@pasteur.fr
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