miércoles, 29 de abril de 2015

Influenza A(H5N8) Virus Similar to Strain in Korea Causing Highly Pathogenic Avian Influenza in Germany - Volume 21, Number 5—May 2015 - Emerging Infectious Disease journal - CDC

full-text ►

Influenza A(H5N8) Virus Similar to Strain in Korea Causing Highly Pathogenic Avian Influenza in Germany - Volume 21, Number 5—May 2015 - Emerging Infectious Disease journal - CDC





Volume 21, Number 5—May 2015

Dispatch

Influenza A(H5N8) Virus Similar to Strain in Korea Causing Highly Pathogenic Avian Influenza in Germany

Timm HarderComments to Author , Sebastian Maurer-Stroh, Anne Pohlmann, Elke Starick, Detlef Höreth-Böntgen, Karin Albrecht, Gunter Pannwitz, Jens Teifke, Vithiagaran Gunalan, Raphael T.C. Lee, Carola Sauter-Louis, Timo Homeier, Christoph Staubach, Carola Wolf, Günter Strebelow, Dirk Höper, Christian Grund, Franz J. Conraths, Thomas C. Mettenleiter, and Martin Beer
Author affiliations: Friedrich-Loeffler-Institut, Insel Riems, Germany (T. Harder, A. Pohlmann, E. Starick, D. Höreth-Böntgen, J. Teifke, C. Sauter-Louis, T. Homeier, C. Staubach, G. Strebelow, D. Höper, C. Grund, F.J. Conraths, T.C. Mettenleiter, M. Beer)Nanyang Technological University, Singapore (S. Maurer-Stroh); Ministry of Health, Singapore (S. Maurer-Stroh)Agency for Science, Technology and Research, Singapore (S. Maurer-Stroh, V. Gunalan, R.T.C. Lee)County Veterinary Office, Anklam, Germany (K. Albrecht, G. Pannwitz)Agency for Agriculture, Food Security and Fisheries of the German Federal State of Mecklenburg–Western Pomeranio, Rostock, Germany (C. Wolf)

Abstract

Highly pathogenic avian influenza (H5N8) virus, like the recently described H5N8 strain from Korea, was detected in November 2014 in farmed turkeys and in a healthy common teal (Anas crecca) in northeastern Germany. Infected wild birds possibly introduced this virus.
Reassortant highly pathogenic avian influenza (HPAI) viruses of subtype H5N8 were introduced into South Korea in early 2014, possibly by virus-infected wild birds. The virus, which was spread widely by wild birds and within farming networks, caused major outbreaks of HPAI in poultry, was associated with deaths in aquatic wild birds, and spread to Japan (14). Related viruses were detected in China (57), but before early November 2014, the viruses had been confined to eastern Asia. This study sought to confirm the etiology of a major outbreak of HPAI (H5N8) on a turkey farm in northeastern Germany and to determine the virus’s possible origin.
Dr. Harder is head of the Reference Laboratory foe Avian Influenza of the World Organisation for Animal Health and of the German National Reference Laboratory for Avian Influenza at Friedrich-Loeffler-Institute. His work is dedicated to diagnosis and applied research of animal influenza viruses.

Acknowledgments

We gratefully acknowledge the professional aid of veterinarians and field workers and technical laboratory assistance from Diana Wessler, Patrick Zitzow, Sarah Westerhold, and Cornelia Illing. Our sincere thanks also go to colleagues releasing sequences in the GISAID database. A detailed overview of sequences used is provided in the Technical Appendix.
The study has been funded in part by the EU Horizon 2020 program (European Commission Grant Agreement No. 643476 “COMPARE”).

References

  1. Kang HMLee EKSong BMJeong JChoi JGJeong JNovel reassortant influenza A(H5N8) viruses among domestic and wild ducks, South Korea, 2014. Emerg Infect Dis2015;21:298304 . DOIPubMed
  2. Lee YJKang HMLee EKSong BMJeong JKwon YKNovel reassortant influenza A(H5N8) viruses, South Korea, 2014. Emerg Infect Dis.2014;20:10879DOIPubMed
  3. Ku KBPark EHYum JKim JAOh SKSeo SHHighly pathogenic avian influenza A(H5N8) virus from waterfowl, South Korea, 2014. Emerg Infect Dis2014;20:15878 . DOIPubMed
  4. Jeong JKang HMLee EKSong BMKwon YKKim HRHighly pathogenic avian influenza virus (H5N8) in domestic poultry and its relationship with migratory birds in South Korea during 2014. Vet Microbiol2014;173:24957DOIPubMed
  5. Wu HPeng XXu LJin CCheng LLu XNovel reassortant influenza A(H5N8) viruses in domestic ducks, eastern China. Emerg Infect Dis.2014;20:13158DOIPubMed
  6. Fan SZhou LWu DGao XPei EWang TA novel highly pathogenic H5N8 avian influenza virus isolated from a wild duck in China. Influenza Other Respir Viruses. 2014;8:646–53.
  7. Zhao KGu MZhong LDuan ZZhang YZhu YCharacterization of three H5N5 and one H5N8 highly pathogenic avian influenza viruses in China.Vet Microbiol2013;163:3517DOIPubMed
  8. World Organisation for Animal Health. Highly pathogenic avian influenza, Germany. Immediate notification. 2014 June 6 [cited 2014 Nov 10].http://www.oie.int/wahis_2/public/wahid.php/Reviewreport/Review?page_refer=MapFullEventReport&reportid=16474
  9. Gall AHoffmann BHarder TGrund CBeer MUniversal primer set for amplification and sequencing of HA0 cleavage sites of all influenza A viruses. J Clin Microbiol2008;46:25617DOIPubMed
  10. Kim Y-IPascua PNQKwon H-ILim G-JKim E-HYoon S-WPathobiological features of a novel, highly pathogenic avian influenza A(H5N8) virus. Emerg Microbes Infect. 2014;3:e75.
  11. Webb BSali A. Comparative protein structure modeling using MODELLER. Curr Protoc Bioinformatics. 2014;47:5.6.1–5.6.32.
  12. Nguyen LTSchmidt HAvon Haeseler AMinh BQIQ-TREE: a fast and effective stochastic algorithm for estimating maximum likelihood phylogenies. Mol Biol Evol2015;32:26874DOIPubMed
  13. World Health Organization. Antigenic and genetic characteristics of zoonotic influenza viruses and development of candidate vaccine viruses for pandemic preparedness. 2014 Sep [cited 2014 Nov 10]. http://www.who.int/influenza/vaccines/virus/201409_zoonotic_vaccinevirusupdate.pdf?ua=1
  14. European Commission. Council Directive 2005/94/EC of 20 December 2005 on community measures for the control of avian influenza and repealing Directive 92/40/EEC. 2005 [cited 2014 Nov 10]. http://eur-lex.europa.eu/legal-content/EN/TXT/?qid=1415609228714&uri=CELEX:32005L0094

Figures

Table

Technical Appendix

Suggested citation for this article: Harder T, Maurer-Stroh S, Pohlmann A, Starick E, Höreth-Böntgen D, Albrecht A, et al. Influenza A(H5N8) virus similar to strain in Korea causing highly pathogenic avian influenza in Germany. Emerg Infect Dis. 2015 May [date cited].http://dx.doi.org/10.3201/eid2015.141897
DOI: 10.3201/eid2105.141897

No hay comentarios:

Publicar un comentario