domingo, 29 de noviembre de 2015

Hepatitis B virus genotype, mutations, human leukocyte antigen polymorphisms and their interactions in hepatocellular carcinoma: a multi-centre cas... - PubMed - NCBI

Hepatitis B virus genotype, mutations, human leukocyte antigen polymorphisms and their interactions in hepatocellular carcinoma: a multi-centre cas... - PubMed - NCBI



 2015 Nov 16;5:16489. doi: 10.1038/srep16489.

Hepatitis B virus genotype, mutations, human leukocyte antigen polymorphisms and their interactions in hepatocellular carcinoma: a multi-centre case-control study.

Wen J1,2Song C1Jiang D3,4,5Jin T6,7Dai J1Zhu L1,8An J9Liu Y1,10Ma S11Qin N1Liang C1Chen J1Jiang Y1Yang L12Liu J12Liu L13Geng T7,Chen C6,7Jiang J8Chen J14,15Zhu F8Zhu Y8Yu L3Shen H1Zhai X8Xu J3,4,5,16Hu Z1,17.

Abstract

Three genome-wide association studies (GWAS) have been conducted on the genetic susceptibility of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC), two of which consistently identified tagging single nucleotide polymorphisms (SNPs) around HLA-DQ/DR. In contrast, large multi-centre association studies between HBV genotype, mutations and the risk of HCC are relatively rare, and their interactions with host variants are even less. We performed a multi-centre study of 1,507 HBV-related HCC cases and 1,560 HBV persistent carriers as controls to evaluate the effects of HBV genotype, mutations, GWAS-identified HLA-DQ/DR SNPs (rs9272105 and rs9275319) and their interactions on HCC risk. We found HBV genotype C was more frequent in HBV-related HCC. And 11 HBV hotspot mutations were independently and significantly associated with HCC risk. We also detected significant interactions of rs9272105 with both the HBV genotype and mutations. Through stepwise regression analysis, HBV genotype, the 11 mutations, HLA-DQ/DR SNPs, and the interaction of rs9272105 with mutation A1752G were all entered into the HCC prediction model, and the area under the curve for the panel including the HLA-DQ/DR SNPs, HBV genotype and mutations was 0.840. The HBV genotype, the mutations and the HLA-DQ/DR SNPs may serve as biomarkers for the surveillance of HBV persistent carriers.

PMID:
 
26568165
 
[PubMed - in process] 
PMCID:
 
PMC4644975
 
Free PMC Article

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